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In June of 2016, the 11th edition
of the American Chemical Society’s book of Reagent
Chemicals was officially published, which was the culmination of 7 years
work for twenty-five dedicated analytical chemists and their affiliated
organizations who volunteer their time and resources by serving on this ACS
committee. This new compendium
reflects new methodology, updated procedures and more stringent specifications
with regard to chemical reagents used for analytical testing purposes. The front
cover of the book is shown below.
The book is available as both a hard copy and an on-line electronic version.
For more information about the online version, please click on the book cover
The book is available as both a hard copy and an on-line electronic version. For more information about the online version, please click on the book cover below:
Summary of 11th edition of the ACS book
of Reagent Chemicals
The process of updating procedures and
setting new specifications is a time-consuming process and can sometimes take
years to complete. By carrying out various testing protocols including sample
preparation and spike recovery procedures, it ensures that new methods are
rugged, robust and will stand up to scrutiny, wherever the book is used around
the world. Many standards organizations and federal agencies that set
guidelines, specifications and/or analytical testing methods—including the United
States Pharmacopeia (USP) and the U.S. Environmental
Protection Agency (EPA) —require the use of ACS grade reagent chemicals in
many of their test procedures. For that reason, it has become the “de facto”
reference book worldwide for the chemicals used in high-purity laboratory
is a Reagent Chemical?
The specifications in this book are intended to serve for reagent chemicals and standard-grade reference materials to be used in precise analytical work of a general nature. The term “reagent-grade chemical” implies that it is a substance of sufficient purity to be used in most chemical analyses or reactions. Standard-grade reference materials are suitable for preparation of analytical standards used for a variety of applications, including instrument calibration, quality control, analyte identification, method performance, and other applications requiring high-purity materials. It is recognized that there may be special uses for reagents and standard-grade reference materials, which may need to conform to more rigorous specifications. Therefore, where necessary, some of the specifications include requirements and tests for certain specialized uses. However, it is impossible to include specifications for all such uses, and thus, there may be occasions when it will be necessary for the analyst to further purify reagents known to have special purity requirements for certain uses.
in the Eleventh Edition
With the publication of the 11th
edition, some of the many highlights include all the additional
“supplements” posted online since the publication of the 10th
edition in 2009, removal of some obsolete test methods, clearer instructions for
many of the existing ones, and also the introduction of many new methods.
Overall, the safety, accuracy, and ease of use in specifications for
approximately 70 of the 430 listed reagents have been improved, and seven new
reagents have been added. While there are numerous minor changes, such as
incorporation of the2011 International Union of Pure and Applied Chemistry (IUPAC),
including the recalculation and redefinition of some atomic weights. In
particular, there are several changes and additions worth noting:
The old heavy metal, sulfide precipitation
test method is still valid, but has been replaced with inductively coupled
plasma–optical emission spectroscopy
(ICP–OES) for over 50 reagent chemicals.
The use of inductively coupled plasma–mass
spectroscopy (ICP-MS) is highly recommended for analyzing many of the ultra-high
purity acids and chemicals.
The replacement of atomic absorption (AA) with plasma-based
techniques, as long as method validation is carried out.
The replacement of polarography for measuring carbonyl impurities
with gas chromatography–mass spectrometry (GC–MS)
• New methodologies introduced for the first time include liquid chromatography– mass spectrometry (LC–MS) and headspace gas chromatography (HS-GC)
The continuation of green chemistry initiative, which incorporates
fewer toxic chemicals in existing test methodologies.
ACS Book of Reagent Chemicals Reflects the Growing Trend to Replace
Traditional Heavy Metals’ Testing with Modern Plasma-Based Spectrochemical
To learn more about the online version and/or
to place an order for the book please click on the image below: